Thesis M.C. Cnossen

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is often referred to as “the most complex disease in our most complex organ”. Although the research field of TBI is emerging, treatment effectiveness of many interventions is not established yet and the prognosis of TBI, and factors influencing the prognosis, are largely unknown.

In this thesis, we focus on outcome following TBI, with an emphasis on prevalence, predictors and prediction modeling. In addition, we examine whether comparative effectiveness research (CER) could contribute to evidence generation in TBI, by analyzing current guideline adherence, treatment variation and analytical methods.

The thesis consists of 17 chapters (including introduction and discussion) and contains a concise summary of the main results in both English (page 381) and Dutch (page 389). The thesis, as well as the online supplements can be downloaded below.

The thesis was funded by the European Union 7th Framework Program (CENTER-TBI).

Thesis M.C. Cnossen